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In 1994, Pfizer scientists revealed that sildenafil, which besides inhibits the PDE5 enzyme, caused penile erecting in males participating in a clinical meditate of a tenderness medicate. Although ICOS scientists were not examination compound IC351 for treating ED, they accepted its potential usefulness for treating that distract. Soon, in 1994, ICOS standard a patent for combine IC351 (structurally different Viagra and vardenafil), and Phase 1 clinical trials began in 1995.
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